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The FSP1/CoQ10/NADPH system protects cells from ferroptosis in a manner independent of the GPX4 axis by inhibiting lipid peroxidation and ferroptosis through the NAD(P)H-dependent reduction of CoQ10 to ubiquinol (CoQH 2 ) [23]

Prog Biophys Mol Biol 155:2028

2021 Jul 15;35(9):1395-1402

However, creatine is reversibly converted by creatine kinase into creatine phosphate and is irreversibly cyclized into creatinine through spontaneous loss of one molecule of water, as indicated previously